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What is codeine? How does it work (mechanism of action)?
Codeine is a narcotic pain-reliever and cough suppressant similar to
morphine and hydrocodone. Moreover, a small amount of codeine is
converted to morphine in the body. The precise mechanism of action of
codeine is not known; however, like morphine, codeine binds to receptors
in the brain (opioid receptors) that are important for transmitting the
sensation of pain throughout the body and brain. Codeine increases
tolerance to pain, decreasing discomfort, but the pain still is apparent
to the patient. In addition to reducing pain, codeine also causes
sedation drowsiness and depresses breathing. Codeine frequently is
combined with acetaminophen (Tylenol) or aspirin for more effective pain
relief. The FDA approved codeine in 1950.

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What are the uses for codeine?
Codeine is used for the relief of mild to moderately severe pain and for suppressing cough.

What are the side effects of codeine?
-The most frequent side effects of codeine include:
-Lightheadedness
-Dizziness
-Nausea
-Vomiting
-Shortness of breath
-Sedation
-Allergic reactions
-Constipation
-Abdominal pain
-Rash
-Itching

Serious side effects of codeine include:
-Life-threatening respiratory depression
-Severe low blood pressure
-Adrenal insufficiency
-Accidental ingestion of codeine can result in fatal overdose

Is codeine addictive? Is it a controlled substance?
Codeine is habit forming (addictive). Mental and physical dependence can
occur but are unlikely when used for short-term pain relief. Using
codeine during pregnancy can cause opioid withdrawal syndrome in the
newborn, which may be life-threatening if not treated.
If codeine is suddenly withdrawn after prolonged use, symptoms of
withdrawal may develop. The dose of codeine should be reduced gradually
in order to avoid withdrawal symptoms.

Can I drink alcohol with codeine? What other drugs interact with codeine?
Codeine can impair thinking and physical abilities required for driving or operating machinery.
Alcohol and other sedatives such as alprazolam (Xanax) can produce
further brain impairment and even confusion when combined with codeine.
Therefore, alcohol and other sedatives should not be used when taking
codeine.
Drugs that stimulate and also block opioid receptors (for example,
pentazocine) reduce the effect of codeine. Such drugs should not be
combined with codeine.
Drugs that block the action of acetylcholine (anticholinergic drugs)
increase the occurrence of urinary retention and constipation when
combined with codeine.
Monoamine oxidase inhibitors (MAOIs) class of antidepressants (for
example, isocarboxazid [Marplan], phenelzine [Nardil], tranylcypromine
[Parnate], selegiline [Eldepryl], and procarbazine [Matulane])
significantly increase the action of codeine. Codeine should not be used
in patients taking MAOIs or within 14 days of stopping MAOIs.
Quick Guide
Chronic Pain Syndrome: Treatment and Management for CPS
Chronic Pain Syndrome: Treatment and Management for CPS

What is the dosage for codeine? How is it taken?
The usual adult dose of codeine for pain is 15-60 mg every 4-6 hours as needed.
The dose for cough is 10 to 20 mg every 4-6 hours as needed.
The maximum dose for treating cough is 120 mg every 24 hours.