Description
Bretazenil (Ro16-6028) is an imidazopyrrolobenzodiazepine[1] anxiolytic drug which is derived from the benzodiazepine family, and was invented in 1988. It is most closely related in structure to the GABA antagonist flumazenil, although its effects are somewhat different. It is classified as a high-potency benzodiazepine due to its high affinity binding to benzodiazepine binding sites[2][3] where it acts as a partial agonist.[4] Its profile as a partial agonist and preclinical trial data suggests that it may have a reduced adverse effect profile.[5] In particular bretazenil has been proposed to cause a less strong development of tolerance and withdrawal syndrome.[6] Bretazenil differs from traditional 1,4-benzodiazepines by being a partial agonist and because it binds to α1, α2, α3, α4, α5 and α6 subunit containing GABAA receptor benzodiazepine receptor complexes. 1,4-benzodiazepines bind only to α1, α2, α3 and α5 GABAA benzodiazepine receptor complexes.[
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Refund policy
Generally we offer our customers the choice between a partial/full refund or a reship depending on situation.
Please allow 24-48hours for a response to any complaints or concerns.
Example Cases:
1 Sending wrong product – Full refund if also active substance does not match.
2 Sending incorrect amount – Partial refund.
3 not like the product (very rare) – No refund.
4 Product is too weak – No refund – you have developed
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