Description
Adderall XR is a first-choice medication used to treat attention
deficit-hyperactivity disorder (ADHD). It contains the extended-release
(XR) forms of dextroamphetamine and amphetamine salts. This medication
is typically taken once per day and lasts throughout the day, but it’s
common to have difficulty sleeping and a loss of appetite.
Adderall XR doesn’t reach its peak level in the blood until seven hours
after a dose has been taken.
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Common side effects include low blood sugar, nausea, dizziness,
abdominal pain, and pain at the site of injection. Gastrointestinal
side-effects tend to be strongest at the beginning of treatment period
and subside over time. Other serious side effects may include medullary
thyroid cancer, angioedema, pancreatitis, gallbladder disease, and
kidney problems. Use in pregnancy and breastfeeding is of unclear
safety. Liraglutide is a glucagon-like peptide-1 receptor agonist (GLP-1
receptor agonist) also known as incretin mimetics. It works by
increasing insulin release from the pancreas and decreases excessive
glucagon release.
Liraglutide was approved for medical use in the European Union in 2009,
and in the United States in 2010. In 2019, it was the 142nd most
commonly prescribed medication in the United States, with more than 4
million prescriptions.
Liraglutide is a medication used for the treatment of type 2 diabetes or
obesity
Type 2 diabetes
Liraglutide improves control of blood glucose. In patients with high
cardiovascular risk, liraglutide has been shown to reduce the risk for
first occurrence of death from cardiovascular causes, nonfatal
myocardial infarction, or nonfatal stroke. ADA guidelines currently
consider liraglutide a first line pharmacologic therapy for type 2
diabetes (usually together with metformin), specifically for patients
with atherosclerotic cardiovascular disease or obesity. A 2011 Cochrane
review showed a HbA1c reduction of 0.24% more with liraglutide 1.8mg
compared to insulin glargine, 0.33% more than exenatide 10µg twice
daily, sitagliptin and rosiglitazone. In an RCT comparing liraglutide,
glargine, glimepiride, and sitagliptin (all added to metformin) with a
follow-up of 5 years, glargine and liraglutide were modestly more
effective in achieving and maintaining target HbA1c, with no difference
in outcomes of microvascular and cardiovascular disease.
Obesity
Liraglutide may also be used together with diet and exercise for chronic
weight management in adults. Liraglutide has been shown to lead to
greater weight loss than other glucagon-like peptide analogues. where is
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