Description
α-PHiP (also known as α-PiHP), is a stimulant drug of the cathinone
class that has been sold online as a designer drug. It is a positional
isomer of pyrovalerone, with the methyl group shifted from the
4-position of the aromatic ring to the 4-position of the acyl chain. In a
classic 2006 study of pyrrolidinyl cathinone derivatives by Meltzer et
al. at Organix, the alpha-isobutyl derivative of pyrovalerone, O-2494,
was found to have the highest potency in vitro as an inhibitor of the
dopamine transporter of the alpha substituted derivatives tested,
however it was not until ten years later in July 2016 that α-PHiP was
first identified as a designer drug, when it was reported to the EMCDDA
by a forensic laboratory in Slovenia.
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